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25.07.2021 | History

2 edition of DNA Methylation and Cellular Differentiation found in the catalog.

DNA Methylation and Cellular Differentiation

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      • Source title: DNA Methylation and Cellular Differentiation (Cell Biology Monographs)

        LC ClassificationsDec 30, 2011
        The Physical Object
        Paginationxvi, 71 p. :
        Number of Pages48
        ID Numbers
        ISBN 103709187230

        nodata File Size: 3MB.

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DNA Methylation and Cellular Differentiation by Springer Download PDF EPUB FB2

Although no terms were significant, the term with the lowest p value was positive regulation of epithelial differentiation, which was one of the cell types we previously observed to change with disease progression based on EpiDISH estimates. This suggests that H3K4me1-only enhancers might be more susceptible to deactivation by methylation.

DNA methylation and differentiation: HOX genes in muscle cells

In this study, gene-specific differentially methylated regions were localized to enhancer or promoter regions and correlated with differences in the expression of memory-associated genes. We applied HOMER to find peaks using ChIP-seq criteria, we defined peak size to be 2500 bp, we turned off the option of filtering based on local and clonal signal and used BEDTools to intersect bins with genomic intervals such as promoters, genes, and predicted enhancers.

H Illustration of the intersection between genes regulated by 1227 DMEs, and the four clusters of genes identified using single cell RNA-seq analysis.

a Principle component analysis of gene expression. Publisher Name Springer, New York, NY• Although embryonic stem cells ESCs retain their ability to self-renew after the loss of any of the proteins of the methylation machinery [], loss of any one protein does impair the ability of ESCs to properly differentiate in culture [—], and loss of all three Tet proteins causes embryonic lethality [—].

Dnmt3-dependent repression of plasma cell gene expression DNA methylation corresponds with gene expression, where actively transcribed genes are depleted of DNA methylation at promoters and enhancers, but contain high levels of gene-body DNA methylation.


Springer Series in Molecular Biology. In undifferentiated cells, DNA bound by H3K4me1-marked nucleosomes was overall unmethylated ; however, upon differentiation, 5mC accumulated predominantly on H3K4me1 proximal regions. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Schematic representation of structural domains of DNMT family A and TET family B members DNMT3A and DNMT3B have similar domain structures: each contains a PWWP, an ADD, Atrx-DNMT3-DNMT3Land a C-terminal catalytic domain.

"Ras regulation of DNA-methylation and cancer". Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, et al.