1 edition of Comparative efficiencies of dose- and concentration-controlled trials found in the catalog.

Comparative efficiencies of dose- and concentration-controlled trials

Reflections on Primo Levis Thinking

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Published by Administrator in National Library of Canada = Bibliothèque nationale du Canada

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    • National Library of Canada = Bibliothèque nationale du Canada


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      • University Microfilms order no. UMI00396527.Thesis (M.Sc.)--University of Toronto, 1992.Includes bibliographical references.

        StatementNational Library of Canada = Bibliothèque nationale du Canada
        PublishersNational Library of Canada = Bibliothèque nationale du Canada
        Classifications
        LC Classifications1993
        The Physical Object
        Paginationxvi, 102 p. :
        Number of Pages91
        ID Numbers
        ISBN 100315784881
        Series
        1
        2Canadian theses = Thèses canadiennes
        3

        nodata File Size: 5MB.


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064 and of culture-positive influenza 2. In using randomized withdrawal designs, it is important to appreciate the possibility of withdrawal phenomena, suggesting the wisdom of relatively slow tapering. Its ability to minimize bias;• Blinding is intended to minimize the potential biases resulting from differences in management, treatment, or assessment of patients, or interpretation of results that could arise as a result of subject or investigator knowledge of the assigned treatment.

A trial using any of the control types may demonstrate efficacy of the test treatment by showing that it is superior to the control placebo, no treatment, low dose of test drug, active drug. The authors suggested that poor immunogenicity and drift of the circulating A H3N2 viruses might have contributed to the poor vaccine efficacy observed in this study. To compute the corresponding doses and concentrations in the RDCTs and RCCTs, respectively, 2500 individual biomarker values were generated for each target level and the defined models were used to calculate the corresponding individual concentrations and doses necessary to reach the target biomarker levels.

Immunogenicity, Efficacy, and Effectiveness of Influenza Vaccines

Each step in the sequence was defined by a mathematical model which will be described in further detail. Current season vaccination was effective regardless of previous vaccination history. These factors make it difficult to draw generalizable conclusions regarding effectiveness of influenza vaccines for individuals with some health conditions. Dose-response studies can include one or more doses of an active control treatment.